Hypoxia and tumor-associated macrophages
نویسندگان
چکیده
Tumor-associated macrophages (TAMs) provide a significant contribution to tumor growth and metastasis. We demonstrated the existence of two main TAM subsets, differing in activation state and localization. Of these, M2-like TAMs reside in hypoxic regions of the tumor mass and can be used as targets for hypoxia tracers. This said, hypoxia does not regulate the differentiation of TAMs but finely tunes the activity of the M2-like population.
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2014